A CASE OF SEROUS CYSTADENOMA OF THE PANCREAS WITH FOCAL MALIGNANT CHANGES

We present a serous cystadenoma of the pancreas with focal malignant c hanges, and describe its characteristic histological features. On gros s examination, a tumor was present on the anterior surface of the body of the pancreas and measured approx 25 x 25 x 20 mm. Microscopically, most tumor cells showed the typical histological features of serous c ystadenoma, characterized by a microcystic architecture and glycogen-r ich cells with a uniform and bland appearance. However, in some areas, a tendency to papillary structures with fibrovascular cores was noted . These papillary lesions were composed mainly of nonmucinous, glycoge n-poor epithelial cells, the nuclei of which showed a mild atypia. In addition, vascular and perivascular invasion was focally observed. How ever, there was no clinical evidence of local or distant metastasis. F rom these findings, we diagnosed this lesion as a serous cystadenoma o f the pancreas with focal malignant changes rather than a serous cysta denocarcinoma of the pancreas.