STRICTURES OF ASCENDING COLON IN CYSTIC-FIBROSIS AND HIGH-STRENGTH PANCREATIC-ENZYMES

We have observed five children with cystic fibrosis, who presented ove r 2 months, with meconium ileus equivalent that failed to respond to m edical management. At surgery, four had a stricture in the ascending c olon, and all had histopathological changes of post-ischaemic ulcerati on repair, with mucosal and submucosal fibrosis. The only common chang e in the management of these children was a switch from conventional e nteric-coated pancreatic enzymes to high-strength products 12-15 month s before presentation.