BLOOD-LEVELS OF 6-KETO-PROSTAGLANDIN-F(1- ALPHA), THROMBOXANE AND PROSTAGLANDIN-F(2-ALPHA) IN BRONCHIAL-ASTHMA

The study revealed the relation of bronchial asthma (bacterial variant ) clinical pattern to plasma levels of PGF2alpha, 6-keto-PGF1alpha and TxB2. In remission of the disease the above indices are lower. Severe asthma remission is characterized by higher levels of 6-keto-PGF1alph a and TxB2 than moderate asthma one, demonstrates a tendency to growin g PGF2alpha levels, A rise in PGF2alpha and TxB2 in manifest asthma po ints to their participation in bronchospasm formation suggesting an ac tive role of these bronschoconstrictors in asthma pathogenesis. Higher levels of 6-keto-PGF1alpha are of a compensary nature in the pathogen esis of PGF2alpha and TxB2 bronchoconstrictory action, and of damaging nature contributing to the formation of bronchial mucosa edema and br onchial gland hypersecretion.