THE GENERAL-THEORY OF NERVOUS DISORDERS - GENERATIVE, DETERMINANT ANDSYSTEMIC MECHANISMS

The paper deals with the virtually unknown and little studied aspect o f the pathogenesis of nervous disoders, which consists in emergence of new pathological integrations in the central nervous system (CNS). Th e formation and activity of these integrations are realized by endogen ous mechanisms intrinsic to the damaged nervous system. The pathologic al integration of hyperactive neurons as their aggregate is a generato r of pathologically enhanced excitation (GPEE). GPEE is capable of pro ducing intense and uncontrolled impulse flow and developing in certain conditions self-sustained and even increased activity. The CNS region where GPEE is formed, becomes hyperactive, alters the other, linked w ith it, CNS structures and induces the formation of systemic pathologi c integration in the form of a new pathodynamic organization, i. e. pa thologic system (PS). This system-forming CNS region plays a role of a key, determinant part of PS. The main biological feature, which makes PS different from physiological systems, it is inadaptive or direct p athogenic significance for the organism. The neuropathologic syndrome is a clinical manifestation of PS activity. Each neuropathologic syndr ome has an appropriate PS, and its specificity and content depend on w hich CNS structures constitute PS. Due to plasticity processes, the po sitive links between the PS part become consolidated with time and as a result the PS resistance to endogenous sanogenetic mechanisms and cu rative therapeutic treatment increases. In creating GPEE in a certain pathogenetically important CNS region, one can reproduce the correspon ding neuropathologic syndrome in modelling experiments. The basic prin ciple in the treatment of nervous disorders consists in elimination of their pathologic systems. The mechanisms of the development, activity and elimination of GPEEs and PSs are considered.