An. Naikhin et al., UTILIZATION OF SALIVA FOR EXAMINATION OF POSTVACCINATION AND POSTINFECTION IMMUNITY TO INFLUENZA BY ENZYME-IMMUNOASSAY, Voprosy virusologii, 38(5), 1993, pp. 201-204
Paired specimens of blood sera, upper respiratory tract secretions, an
d saliva from healthy, influenza-infected, and live influenza trivacci
ne-immunized humans were tested in parallel by HI tests and enzyme imm
unoassay (EIA). The resulting comparative data suggest that determinat
ion by EIA of specific secretory IgA in the saliva may be recommended
as an independent test for large-scale influenza diagnosis, evaluation
of the immune status of people, and trials of influenza vaccines. By
immunologic parameters, this method is not inferior to the standard on
es. At the same time its advantages include simplicity and readily ava
ilable large volumes of saliva even from children as well as no necess
ity to bleed subjects to be examined.