COMPARATIVE-EVALUATION OF IMMUNOGENICITY AND REACTOGENICITY OF RECOMBINANT VACCINES AGAINST HEPATITIS-B

Controlled epidemiological studies were carried out to evaluate two re combinant vaccines against-hepatitis B of Guban and Belgian production by the parameters of reactogenicity, safety and antigenic activity. T wo groups of adult subjects (n=73 each) and two groups of children (n= 30 each) were selected among those free from hepatitis B markers carri er state. The adults were given both preparations in a dose of 20 mug at intervals of 0-1-4 months, and the children received 10 mug at 0-1- 2 months. The comparative studies showed both vaccines to be poorly re actogenic, safe and inducing anti-Hns in 80-100 % of triply vaccinated subjects in titres within 100-500 IU. No statistically significant di fferences in the examined parameters were found in the two preparation s tested.