EXPERIMENTAL-MODEL OF COXSACKIE GROUP ENT EROVIRUSES VERTICAL TRANSMISSION AND UTILIZATION THEREOF IN THE DEVELOPMENT OF METHODS FOR PREVENTION OF CONGENITAL COXSACKIE-VIRUS INFECTION

An experimental model of vertical transmission of Coxsackie group ente roviruses was developed in BALB/c mice the first generation of which w as infected with Coxsackie A18 virus in the neonatal period. Persisten ce of the virus was demonstrated in all females of the first generatio n tested and in 90.9 % to 100 % of the animals of the next two generat ions. Cytochemical analysis of the enzyme status of lymphocytes reveal ed reliable relationship between the depression of energetic metabolis m enzymes and the activity of virus amplification in the animals under study. The correction of aerobic respiration in pregnant females by a dministration of a complex of energy metabolism substrates and cofacto rs was accompanied by a significant reduction of the virus infection a ctivity in the females and their offsprings as well as by prevention o f transplacental infection in some litters. The experimental model of vertical transmission of enteroviruses is proposed for use in the deve lopment of methods for prevention of congenital Coxsackie virus infect ion.