The effects of repeated administrations of neuropsychological instrume
nts were evaluated in a group of chronic cigarette smokers who served
as control subjects in a larger research project. Subjects performance
on 13 neuropsychological variables across four assessments was evalua
ted using trend analyses. Statistically significant results were obtai
ned on the Logical and Figural Memory Subtests of the Wechsler Memory
Scale (Form I - Russell's Revision) Part B of the Trail Making Test an
d the Grooved Pegboard Test (preferred hand). Of the remaining seven v
ariables the Speech Sounds Perception Test, the Seashore Rhythm Test a
nd Simple Auditory Reaction Time were highly consistent across all fou
r assessments. The implications of these findings in clinical practice
and research settings are addressed.