STRUCTURAL ORGANIZATION OF THE GENES ENCODING HUMAN AND MURINE FK506-BINDING PROTEIN (FKBP)13 AND COMPARISON TO FKBP1

Authors
HENDRICKSON BA ZHANG W CRAIG RJ JIN YJ BIERER BE BURAKOFF S DILELLA AG
Citation
Ba. Hendrickson et al., STRUCTURAL ORGANIZATION OF THE GENES ENCODING HUMAN AND MURINE FK506-BINDING PROTEIN (FKBP)13 AND COMPARISON TO FKBP1, Gene, 134(2), 1993, pp. 271-275
Citations number
27
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
134
Issue
2
Year of publication
1993
Pages
271 - 275
Database
ISI
SICI code
0378-1119(1993)134:2<271:SOOTGE>2.0.ZU;2-M
Abstract
FK506-binding protein (FKBP)12 and FKBP13 are members of a family of p roteins which bind the immunosuppressant drugs, FK506 and rapamycin. F KBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and F KBP2, respectively. The structure of human FKBP1 was previously charac terized. We now report the genomic structure of the human and murine F KBP2 genes. Comparison of FKBP1 and FKBP2 reveals significant homology and correlation of intron positions in the C-terminal region, suggest ing that these genes may have evolved from a common ancestral gene.