SYNTHESIS OF A NEW SERIES OF 8-SUBSTITUTED-2,8-DIAZASPIRO[4.5]DECAN-3-ONES

Authors
CIGNARELLA G VILLA S BARLOCCO D
Citation
G. Cignarella et al., SYNTHESIS OF A NEW SERIES OF 8-SUBSTITUTED-2,8-DIAZASPIRO[4.5]DECAN-3-ONES, Journal of heterocyclic chemistry, 30(5), 1993, pp. 1357-1359
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
30
Issue
5
Year of publication
1993
Pages
1357 - 1359
Database
ISI
SICI code
0022-152X(1993)30:5<1357:SOANSO>2.0.ZU;2-F
Abstract
A new series of 8-substituted-2,8-diazaspiro[4.5]decan-3-ones has been synthesized and tested in in vitro and in vivo assays predictive for cholinergic activity, in comparison with the muscarinic agent RS-86. P reliminary pharmacological data indicate that the compounds are devoid of significant cholinergic properties.