NONINVASIVE MEASUREMENT OF REGIONAL CEREBRAL BLOOD-FLOW CHANGE WITH (H2O)-O-15 AND POSITRON EMISSION TOMOGRAPHY USING A MECHANICAL INJECTORAND A STANDARD ARTERIAL INPUT FUNCTION
N. Sadato et al., NONINVASIVE MEASUREMENT OF REGIONAL CEREBRAL BLOOD-FLOW CHANGE WITH (H2O)-O-15 AND POSITRON EMISSION TOMOGRAPHY USING A MECHANICAL INJECTORAND A STANDARD ARTERIAL INPUT FUNCTION, IEEE transactions on medical imaging, 12(4), 1993, pp. 703-710
Citations number
19
Categorie Soggetti
Engineering, Biomedical","Radiology,Nuclear Medicine & Medical Imaging
To estimate changes in regional cerebral blood flow (rCBF) without art
erial sampling in the study of functional-anatomical correlations in t
he hunan brain, using O-15-labeled water and PET, a standard arterial
input function was generated from the Input function in 10 normal volu
nteers with dose calibration and peak time normalization. The speed an
d volume of injection were precisely controlled with a mechanical inje
ctor. After global normalization of each tissue activity image, the st
andard arterial input function was applied to obtain estimated CBF ima
ges. Relative changes in estimated rCBF to whole brain mean CBF(Delta
Fest) and those in regional tissue activity (Delta C) were compared wi
th true relative rCBF changes (Delta F) in 40 pairs of images obtained
from 6 normal volunteers. Delta Fest correlated web with Delta F, whe
reas Delta C consistently underestimated Delta F. This noninvasive met
hod simplifies the activation studies and provides the accurate estima
tion of relative how changes.