OPTICALLY-ACTIVE 2-CYMANTRENYLOXAZOLINES - SYNTHESIS AND REGIOSELECTIVE METALATION

Three optically active oxazolines with a cymantrenyl substituent at po sition 2 of the heterocycle have been prepared. Metallation of these c ompounds with n-BuLi proceeds only at the two diastereotopic alpha- an d alpha'-positions of the Cp-ring to an equal extent. The dependence o f the sign of Cotton effect in the region of 300-350 nm upon the absol ute configuration of chiral centers remote from the Cp-ring has been d emonstrated.