Gj. Amabeoku et O. Chikuni, CIMETIDINE-INDUCED SEIZURES IN MICE - ANTAGONISM BY SOME GABAERGIC AGENTS, Biochemical pharmacology, 46(12), 1993, pp. 2171-2175
The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric
acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam,
phenobarbitone and phenytoin on cimetidine induced seizures were stud
ied in mice. Cimetidine (400-1000 mg/kg, i.p.) induced dose-dependent
tonic convulsion. Muscimol, AOAA and DABA effectively protected mice a
gainst cimetidine-induced seizures. Bicuculline and picrotoxin signifi
cantly potentiated the seizures induced by cimetidine and effectively
antagonized the protective e:ffects of muscimol, AOAA and DABA against
the seizures. Diazepam and phenobarbitone significantly protected the
mice against cimetidine-induced seizures while phenytoin and strychni
ne did not significantly alter the seizures. These results indicate th
at the attenuation of central gamma-aminobutyric acid neurotransmissio
n may underlie cimetidine-induced seizures in mice.