There is now considerable evidence linking the severity of gallstone-a
ssociated acute pancreatitis with obstruction to both the bile duct an
d the pancreatic duct by ''persisting'' stones either because of conti
nuous or repeated impaction, or repeated passage. Two prospective tria
ls have shown endoscopic sphincterotomy to be superior to other forms
of treatment, but only in severe cases, and general experience now ext
ends to over 1000 cases so treated. Endoscopic sphincterotomy is also
very effective in acute pancreatitis associated with acute cholangitis
. Prophylactic endoscopic sphincterotomy may be of benefit in elderly
patients in preference to prophylactic cholecystectomy. Yet to be full
y explored is the role of this procedure in the early treatment of sev
ere non-gallstone pancreatitis and in established pancreatic necrosis.