MARKERS OF EOSINOPHILIC INFLAMMATION IN ALLERGIC DISEASES

The paper reviews personal studies aimed at identifying clinical marke rs of eosinophil inflammation in allergic diseases. Preliminary data o n the use of how cytometry as a method to detect eosinophil activation through phenotypic activation markers are reported. The concept of eo sinophil releasability is introduced on the basis of in vitro eosinoph il activation and mediator release by different stimuli. Data showing an increase of serum levels of ECP mainly in subjects with sensitivity to perennial allergens and related to histamine bronchial reactivity are discussed in view of their practical impact in diagnosing and moni toring of allergic diseases and asthma.