A previously unreported form of localized bullous scabies mimicking bu
llous pemphigoid is described. The patient presented with a localized,
severely pruritic erythematous plaque with a cutaneous eruption consi
sting of several papules and a single tense bulla on an erythematous b
ase. The histologic findings consisted of a subepidermal inflammatory
bullous dermatosis with lymphocytes, neutrophils, and many eosinophils
, and the results of direct immunofluorescence were negative. Correlat
ion of the clinical course with the histologic and immunofluorescence
findings were necessary to establish the diagnosis of infestation by S
arcoptes scabiei.