INTRAPERITONEAL CARBOPLATIN IN THE TREATMENT OF BULKY DISEASE OVARIAN-CANCER - EXPERIENCE IN 2 CASES

Background: Intraperitoneal (i.p.) chemotherapy (CT) is an attractive treatment modality for cancers usually restricted to the peritoneal ca vity. This seems to be particular true for ovarian cancer. Patients an d Methods: Here we describe our experience in 2 heavily pretreated pat ients with progressive bulky disease ovarian carcinoma treated by i.p. carboplatin. Results: The 1st woman showed stable disease for 16 mont hs, the 2nd a partial remission lasting 5 months. Toxicities and side effects of i.p. CT were mild, the patients remained in good physical c ondition. Conclusions: 1) i.p. carboplatin is a well-tolerated treatme nt modality, and 2) it can produce objective clinical responses in som e patients with bulky ovarian carcinoma. This treatment modality shoul d be considered for further clinical evaluation, especially for pallia tive purpose.