THE CALIBRATION OF AN OPTICAL IMMUNOSENSOR - THE FCFD

The calibration of immunosensors is a major technical challenge to be overcome before such devices achieve commercial acceptance. This paper reports a method for calibrating one optical immunosensor, the fluore scence capillary fill device (FCFD), which functions by exploitation o f the physical structure of the device, precomplexing reagents within the device and appropriate signal processing. This enables a calibrati on system to function in the sample of interest and in the presence of the analyte under assay.