REGULATION OF GROWTH-HORMONE SECRETION BY THE GROWTH-HORMONE RELEASING HEXAPEPTIDE (GHRP-6)

Authors
MICIC D MALLO F PEINO R CORDIDO F LEALCERRO A GARCIAMAYOR RVG CASANUEVA FF
Citation
D. Micic et al., REGULATION OF GROWTH-HORMONE SECRETION BY THE GROWTH-HORMONE RELEASING HEXAPEPTIDE (GHRP-6), Journal of pediatric endocrinology, 6(3-4), 1993, pp. 283-289
Citations number
27
Categorie Soggetti
Pediatrics,"Endocrynology & Metabolism
Journal title
Journal of pediatric endocrinology → ACNP
Volume
6
Issue
3-4
Year of publication
1993
Pages
283 - 289
Database
ISI
SICI code
Abstract
Growth hormone (GH) secretion is regulated by a complex system of cent ral and peripheral signals. Recently, a new GH-releasing hexapeptide ( His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) called GHRP-6 which specifically rele ases GH has been studied. In the present work the mechanism of action of GHRP-6 has been addressed in experimental animal models as well as in obese subjects. GHRP-6 releases GH independently of the hypothalami c factors GHRH and somatostatin and is a powerful GH releaser in obesi ty.