PREPARATION OF THE ISOFLURANE ENANTIOMERS

Authors
HUANG CG ROZOV LA HALPERN DF VERNICE GG
Citation
Cg. Huang et al., PREPARATION OF THE ISOFLURANE ENANTIOMERS, Journal of organic chemistry, 58(26), 1993, pp. 7382-7387
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
58
Issue
26
Year of publication
1993
Pages
7382 - 7387
Database
ISI
SICI code
0022-3263(1993)58:26<7382:POTIE>2.0.ZU;2-5
Abstract
The enantiomers of the inhalation anesthetic agent, isoflurane (1-chlo ro-2,2,2-trifluoroethyl difluoromethyl ether), are prepared by a synth esis starting from 2,2,2-trifluoroethanol. (R)-(+)-Dehydroabietylamine is used as the resolving agent for the racemic acid intermediate 1. T he optical purities of both (S)-(+)- and (R)-(-)-isofluranes are deter mined to be >99% ee (enantiomeric excess) by chiral capillary gas chro matography.