A CASE OF GIANT CONDYLOMA ACUMINATUM - DI FFERENTIAL-DIAGNOSIS OF GIANT CONDYLOMAS FROM BUSCHKE-LOWENSTEIN TUMORS

We report on a 67-year-old man with a large papillomatous tumour of th e penis clinically resembling verrucous carcinoma. HPV 6 and HPV 11 DN A could be isolated by hybridization techniques. The tumour showed exc lusively exophytic growth with anastomosing acanthosis and papillomato sis. Groups of vacuolated cells were present in the spinous and granul ar layers. Endophytic and destructive proliferations and cytologic cri teria of malignancy were absent. This tumor was a giant condyloma acum inatum and not either a Buschke-Lowenstein tumour or a verrucous carci noma. There was no recurrence 2 years after local excision. The differ ential diagnosis of giant condylomas and Buschke-Lowenstein tumours is discussed.