A patient with advanced HIV infection developed multiple angiomatous p
apules and nodules on the upper chest within a few days. At first sigh
t the lesions resembled disseminated Kaposi's sarcoma; the differentia
l diagnosis, however, included eruptive haemangiomas and pyogenic gran
ulomas. Such distinct clinical characteristics as the collarette-like
desquamation at the borders of the tumours led to the suspicion of bac
illary epithelioid angiomatosis in HIV infection, which was then confi
rmed by histology and ultrastructural demonstration of bacillary colon
ies within the lesions. Under systemic antibiotic treatment, marked re
gression of the lesions was quickly observed within 1 week and complet
e regression occurred after 4 weeks. It is important to consider bacil
lary angiomatosis in HIV infection in the differential diagnosis of Ka
posi's sarcoma, and it is a separate entity in the form of angioprolif
eration caused by bacteria.