SUCCESSFUL LONG-TERM KETOCONAZOLE TREATMENT OF HYPERADRENOCORTICISM IN A DOG

Authors
JANSSENS LAA JANSSENS DL
Citation
Laa. Janssens et Dl. Janssens, SUCCESSFUL LONG-TERM KETOCONAZOLE TREATMENT OF HYPERADRENOCORTICISM IN A DOG, Vlaams dierengeneeskundig tijdschrift, 62(6), 1993, pp. 186-188
Citations number
NO
Categorie Soggetti
Veterinary Sciences
Journal title
Vlaams dierengeneeskundig tijdschrift → ACNP
ISSN journal
03039021
Volume
62
Issue
6
Year of publication
1993
Pages
186 - 188
Database
ISI
SICI code
0303-9021(1993)62:6<186:SLKTOH>2.0.ZU;2-7
Abstract
An II years old poodle was treated successfully for Cushing's disease with ketoconazole for a period of two years. Ketoconazole dosage was a dapted to allow a urinary corticoid/creatinine ratio of ca. 10.10(-6). Endogenous cortisol production was found to be suppressed excessively 12 months after the onset of treatment, but was restored by decreasin g the dose of ketoconazole. The patient was euthanised twenty-three mo nths after starting therapy because of kidney failure.