ACUTE ADMINISTRATION OF THYROTROPIN-RELEASING-HORMONE AFTER FOCAL CEREBRAL-ISCHEMIA - PHARMACO-ELECTROENCEPHALOGRAPHIC STUDY

Authors
TEDESCHI G DONOFRIO F SALVIA S PETRETTA V BONAVITA V
Citation
G. Tedeschi et al., ACUTE ADMINISTRATION OF THYROTROPIN-RELEASING-HORMONE AFTER FOCAL CEREBRAL-ISCHEMIA - PHARMACO-ELECTROENCEPHALOGRAPHIC STUDY, Current therapeutic research, 54(6), 1993, pp. 649-657
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
Journal title
Current therapeutic research → ACNP
ISSN journal
0011393X
Volume
54
Issue
6
Year of publication
1993
Pages
649 - 657
Database
ISI
SICI code
0011-393X(1993)54:6<649:AAOTAF>2.0.ZU;2-U
Abstract
A total of 20 patients who had suffered a stroke 1 to 3 months before initiation of the study underwent electroencephalographic (EEG) mappin g for up to 2 hours after administration of 4 mg of thyrotropin-releas ing hormone (TRH) or placebo. TRH administration modified the absolute values of cerebral electrical activity. The relative power intensity within the theta and alpha bands was significantly affected by TRH. Th e peak effect was observed 30 minutes after administration. Placebo ad ministration had no significant effect on EEG mapping.