The results of thoracoscopic biopsy and talc pleurodesis in the manage
ment of malignant pleural effusions, is analysed. The study population
consisted of 213 patients. Pre-operative cytology was positive in onl
y 27% of patients; the diagnostic yield using thoracoscopic biopsy was
91.5%. (Sensitivity 99%; specificity 100%; positive predicted value 1
00%; negative predicted value 88%). Talc pleurodesis at thoracoscopy p
roduced symptomatic improvement in 93% of patients. Post-operative com
plications occurred in 3.7% and there was a 2.3% mortality. Recurrent
effusion was not a significant clinical problem. Thoracoscopy enhances
the accuracy of diagnosis of pleural effusions; simultaneous talc ple
urodesis has a high therapeutic success.