GENETIC CORRELATIONS BETWEEN BRAIN DOPAMI NE METABOLISM AND ANXIETY IN MICE

Citation
Nk. Popova et al., GENETIC CORRELATIONS BETWEEN BRAIN DOPAMI NE METABOLISM AND ANXIETY IN MICE, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 46(5), 1996, pp. 904-910
Citations number
19
Categorie Soggetti
Physiology,Neurosciences
ISSN journal
00444677
Volume
46
Issue
5
Year of publication
1996
Pages
904 - 910
Database
ISI
SICI code
0044-4677(1996)46:5<904:GCBBDN>2.0.ZU;2-U
Abstract
Dopamine, homovanillic acid(HVA) and 3,4-dihydroxyphenylacetic acid (D OPAC) levels were determined in striatum and nucleus accumbens with ol factory tubercles in four mice strains (C57BL/6, DBA/2, BALB/c, and CB A). The levels of anxiety were estimated in the elevated plus-maze, da rk-light test, and by the social activity. Significant correlation was revealed between the content of dopamine (and its main metabolites) a nd the lever of anxiety. All the correlations between the DOPAC level and the percentage of time spent in the open arms, or at the illuminat ed area, or contacting with a conspecific were positive. The correlati ons between these anxiety indices and HVA levels were negative. It is suggested that brain dopaminergic system plays an essential role in th e regulation of anxiety and that anxiety is associated with increased O-methylation and decreased oxidative deamination of dopamine.