ALTERATION OF THE VOLTAGE-DEPENDENCE OF THE TWITCH TENSION IN FROG SKELETAL-MUSCLE FIBERS BY A POLYETHER, BISTRAMIDE-A

Citation
Mp. Sauviat et Jf. Verbist, ALTERATION OF THE VOLTAGE-DEPENDENCE OF THE TWITCH TENSION IN FROG SKELETAL-MUSCLE FIBERS BY A POLYETHER, BISTRAMIDE-A, General physiology and biophysics, 12(5), 1993, pp. 465-471
Citations number
16
Categorie Soggetti
Physiology,Biophysics
ISSN journal
02315882
Volume
12
Issue
5
Year of publication
1993
Pages
465 - 471
Database
ISI
SICI code
0231-5882(1993)12:5<465:AOTVOT>2.0.ZU;2-D
Abstract
Bistramide A, a toxin isolated from Lissoclinum bistratum Sluiter, was applied to frog skeletal muscle fibres. Micromolar concentrations of toxin decreased the amplitude of the twitch tension. Bistramide A shif ted the activation and the steady-state inactivation characteristics o f the tension on the voltage axis towards more positive and negative m embrane potentials respectively. The data suggest that Bistramide A bi nds to the activated and inactivated state of the dihydropyridine-rece ptor which senses the T-tubule membrane potential.