Mp. Sauviat et Jf. Verbist, ALTERATION OF THE VOLTAGE-DEPENDENCE OF THE TWITCH TENSION IN FROG SKELETAL-MUSCLE FIBERS BY A POLYETHER, BISTRAMIDE-A, General physiology and biophysics, 12(5), 1993, pp. 465-471
Bistramide A, a toxin isolated from Lissoclinum bistratum Sluiter, was
applied to frog skeletal muscle fibres. Micromolar concentrations of
toxin decreased the amplitude of the twitch tension. Bistramide A shif
ted the activation and the steady-state inactivation characteristics o
f the tension on the voltage axis towards more positive and negative m
embrane potentials respectively. The data suggest that Bistramide A bi
nds to the activated and inactivated state of the dihydropyridine-rece
ptor which senses the T-tubule membrane potential.