CLINICAL-TRIALS IN GENE-THERAPY

Retroviral-mediated gene transfer has permitted the development of cli nical protocols for the study and treatment of genetic diseases and ca ncer. These protocols can be divided into proposals either for gene la belling (transfer) or for gene therapy. Labelling studies include the tracking of gene-modified cells (e.g., tumor-infiltrating lymphocytes, bone marrow tumor cells) infused into the patient. Most gene therapy protocols are designed to deliver a therapeutic protein using a mature differentiated cell population (e.g., fibroblasts). A number of proto cols to treat genetic diseases and cancer have been recently initiated . The approval process for the clinical studies requires a multi-agenc y review due to the safety and ethical concerns. While safety issues o f the procedure still exist, gene therapy holds much promise as an eff ective treatment modality.