CORRELATION OF P53 WITH THE CLINICOPATHOLOGICAL FEATURES AND PROGNOSIS OF COLORECTAL ADENOCARCINOMA

Immunohistochemical staining of p53 was performed using an anti-p53 mo use monoclonal antibody, Pab1801, on 67 colorectal adenocarcinoma spec imens to determine the prognostic value of p53 in colorectal cancer pa tients. Of a total of 67 tumors examined, p53 was detected in 34, but the rate of positive staining for p53 did not correlate with the clini cal stage of disease. In 59 patients undergoing curative resection of the tumor, there was no significant difference in the recurrence rate (P = 0.137) or the disease-free survival rate between 28 patients with p53 positive tumors and 31 with p53 negative tumors (P = 0.135).