ASYMMETRIC SYNTHESES OF (S)-FENFLURAMINE USING SHARPLESS EPOXIDATION METHODS

Authors
GOUMENT B DUHAMEL L MAUGE R
Citation
B. Goument et al., ASYMMETRIC SYNTHESES OF (S)-FENFLURAMINE USING SHARPLESS EPOXIDATION METHODS, Tetrahedron, 50(1), 1994, pp. 171-188
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
1
Year of publication
1994
Pages
171 - 188
Database
ISI
SICI code
0040-4020(1994)50:1<171:ASO(US>2.0.ZU;2-M
Abstract
We describe one synthesis of (S)-fenfluramine and several syntheses of its precursors (R)- and (S)-1-(meta-trifluoromethylphenyl) propan-2-o ls. They were obtained from the asymmetric epoxidation of the primary allylic alcohol 5 and from the kinetic resolution with asymmetric epox idation of the secondary allylic alcohol 6.