A CONVENIENT SYNTHESIS OF 5-DEAZA NONCLASSICAL ANTIFOLATES - REACTIONOF CYANOTHIOACETAMIDE WITH SODIUM-SALTS OF 2-(HYDROXYMETHYLENE)-1-CYCLOALKANONES

Authors
ELGEMEIE GEH HUSSAIN BAW
Citation
Geh. Elgemeie et Baw. Hussain, A CONVENIENT SYNTHESIS OF 5-DEAZA NONCLASSICAL ANTIFOLATES - REACTIONOF CYANOTHIOACETAMIDE WITH SODIUM-SALTS OF 2-(HYDROXYMETHYLENE)-1-CYCLOALKANONES, Tetrahedron, 50(1), 1994, pp. 199-204
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
1
Year of publication
1994
Pages
199 - 204
Database
ISI
SICI code
0040-4020(1994)50:1<199:ACSO5N>2.0.ZU;2-H
Abstract
Condensation of cyanothioacetamide with sodium salts of 2-(Hydroxymeth ylene)-1-cycloalkanones afforded the corresponding pyridine-2(1H)-thio nes 4. Compounds 4 served as a key intermediates for the synthesis of condensed 2,4-diaminopyrido[2,3-d]pyridines 7. Compounds 7 were of int erest as potential inhibitors of dihydrofolate reductase.