SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME L-1-(2-THIAZOLYL)PYRAZOLO[4,3-C][1,2]BENZOTHIAZINE 5,5-DIOXIDES

Authors
SHARMA PK SAWHNEY SN
Citation
Pk. Sharma et Sn. Sawhney, SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME L-1-(2-THIAZOLYL)PYRAZOLO[4,3-C][1,2]BENZOTHIAZINE 5,5-DIOXIDES, Bulletin of the Chemical Society of Japan, 66(12), 1993, pp. 3843-3846
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Chemical Society of Japan → ACNP
ISSN journal
00092673
Volume
66
Issue
12
Year of publication
1993
Pages
3843 - 3846
Database
ISI
SICI code
0009-2673(1993)66:12<3843:SAAAOS>2.0.ZU;2-I
Abstract
Condensation of l-1-thiocarbamoylpyrazolo[4,3-c][1,2]benzothiazine 5,5 -dioxide with various phenacyl bromides, ethyl 3-aroyl-3-bromopropiona tes, and ethyl bromopyruvate afforded (2-thiazolyl)pyrazolo[4,3-c][1,2 ]benzothiazine-5,5 dioxides, which were also prepared by an alternate route in order to confirm their structure, were tested for antiinflamm atory activity by carrageenan-induced rat paw edema test. The compound s have shown moderate to good activity.