Mj. Simons et al., STRATEGY FOR DEFINITION OF DR DQ HAPLOTYPES IN THE 4AOHW CELL PANEL USING NONCODING SEQUENCE POLYMORPHISMS/, Human immunology, 38(1), 1993, pp. 69-74
Our previously described intron-based DQA1-typing method provides 11 a
llelic and suballelic groups, including the eight alleles encoded at t
he second exon. Concurrent testing for the presence of the DRB3, DRB4,
and DRB5 loci and the Rsa I pattern of the DRw52 group simplifies the
typing requirements for allele assignment at the highly polymorphic D
RB1 locus. The DRB1-allele-shortlisting process relies on known DR/DQ
haplotypes. In addition to reducing the testing requirements for defin
itive DRB1 allele assignment, this strategy allows inference of the DR
/DQ haplotype and assists in recognition of novel and/or unusual assoc
iations.