PARANEOPLASTIC PSEUDOOBSTRUCTION, MONONEUROPATHY MULTIPLEX, AND SENSORY NEURONOPATHY

A patient with mononeuropathy multiplex, sensory neuronopathy, and dif fuse intestinal pseudo-obstruction consisting of gastroparesis and imp aired small and large bowel motility was found to have a small cell ca rcinoma of the lung. The constellation of findings were indicative of paraneoplastic neuropathy, which was confirmed with the appropriate an tibody studies demonstrating antineuronal nuclear antibodies. Identifi cation of paraneoplastic neuropathy is important, since early treatmen t of the primary cancer, which is virtually always a small cell carcin oma of the lung, may halt the progression of the disorder. (C) 1994 Jo hn Wiley and Sons, Inc.