TEMPLATE ASSEMBLED SYNTHETIC PROTEINS - CONDENSATION OF A MULTIFUNCTIONAL PEPTIDE TO A TOPOLOGICAL TEMPLATE VIA CHEMOSELECTIVE LIGATION

A chemoselective ligation via oxime bond formation is used for the che mical synthesis of template assembled peptides according to the TASP ( Template Assembled Synthetic Proteins) approach. Aminooxyacetylation o f the multifunctional partial sequence Lys- Arg- Asp- Ser of lactoferr in and subsequent condensation in aqueous solution with a topological template containing four selectively addressable aldehyde functions as attachment sites gives readily access to the TASP molecule.