SYNTHESIS OF ALPHA-SUBSTITUTED AND ALPHA,ALPHA-DISUBSTITUTED ALPHA-AMINO-ACID BY CONTROLLED MONOALKYLATION AND DIALKYLATION OF ETHYL N-DIPHENYLMETHYLENEGLYCINATE

Authors
EZQUERRA J PEDREGAL C MORENOMANAS M PLEIXATS R ROGLANS A
Citation
J. Ezquerra et al., SYNTHESIS OF ALPHA-SUBSTITUTED AND ALPHA,ALPHA-DISUBSTITUTED ALPHA-AMINO-ACID BY CONTROLLED MONOALKYLATION AND DIALKYLATION OF ETHYL N-DIPHENYLMETHYLENEGLYCINATE, Tetrahedron letters, 34(52), 1993, pp. 8535-8538
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
52
Year of publication
1993
Pages
8535 - 8538
Database
ISI
SICI code
0040-4039(1993)34:52<8535:SOAAAA>2.0.ZU;2-W
Abstract
Ethyl N-diphenylmethyleneglycinate reacts with one equivalent of alkyl ating agents in the presence of powdered potassium carbonate to afford , after hydrolysis, monoalkylated glycine esters. A similar process us ing two equivalents of alkylating agents in the presence of powdered p otassium hydroxide and a phase transfer catalysts gives, after hydroly sis, dialkylated glycine esters.