ASYMMETRIC ANTI-SELECTIVE ALDOL REACTIONS OF TITANIUM Z-ENOLATES DERIVED FROM N-ALKYLIDENEGLYCINAMIDES BEARING A 2,2-DIMETHYLOXAZOLIDINE CHIRAL CONTROLLER

Authors
KANEMASA S MORI T TATSUKAWA A
Citation
S. Kanemasa et al., ASYMMETRIC ANTI-SELECTIVE ALDOL REACTIONS OF TITANIUM Z-ENOLATES DERIVED FROM N-ALKYLIDENEGLYCINAMIDES BEARING A 2,2-DIMETHYLOXAZOLIDINE CHIRAL CONTROLLER, Tetrahedron letters, 34(51), 1993, pp. 8293-8296
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
51
Year of publication
1993
Pages
8293 - 8296
Database
ISI
SICI code
0040-4039(1993)34:51<8293:AAAROT>2.0.ZU;2-Y
Abstract
Asymmetric aldol reactions of titanium Z-enolates of N-diphenylmethyle ne derivatives of glycinamides derived from (4S)-2,2-dimethyloxazolidi ne chiral auxiliaries are highly ul,ul-1,4-inductive. Hydrolytic remov al of the chiral auxiliary from the aldol adducts provide optically ac tive anti-isomers of alpha-amino-beta-hydroxy acids with 2R-absolute c onfiguration.