DIFFERENT ELIMINATION OF CIRCULATING IGA IMMUNE-COMPLEXES IN RAT AND GUINEA-PIG - BLOOD CLEARANCE, ORGAN DISTRIBUTION AND CELLULAR UPTAKE IN THE LIVER

Citation
Ag. Johansson et T. Skogh, DIFFERENT ELIMINATION OF CIRCULATING IGA IMMUNE-COMPLEXES IN RAT AND GUINEA-PIG - BLOOD CLEARANCE, ORGAN DISTRIBUTION AND CELLULAR UPTAKE IN THE LIVER, International archives of allergy and immunology, 103(1), 1994, pp. 36-43
Citations number
58
Categorie Soggetti
Allergy,Immunology
ISSN journal
10182438
Volume
103
Issue
1
Year of publication
1994
Pages
36 - 43
Database
ISI
SICI code
1018-2438(1994)103:1<36:DEOCII>2.0.ZU;2-1
Abstract
Soluble IgA immune complexes, formed between I-125-labelled dinitrophe nyl-conjugated human serum albumin and mouse IgA anti-dinitrophenyl an tibodies (MOPC 315), were given intravenously to rats and guinea pigs. Blood clearance kinetics and organ distribution of radioactivity were measured after 15 min. Radioactivity was quantified in isolated paren chymal cells, Kupffer cells (KCs) and liver endothelial cells. IgA com plexing did not affect the antigen blood clearance kinetics in either species. In rats, IgA increased the total hepatic antigen uptake, owin g to a vast increase in the uptake by parenchymal cells. No IgA-mediat ed effect could be shown in KCs, still about 40-50% of the hepatic upt ake was confined to KCs. In guinea pigs there was also an IgA-mediated increase in hepatic uptake, but here the increase could be ascribed t o the KCs alone.