STRUCTURE, SYNTHESIS, AND ANTITUMOR-ACTIVITY OF THE HYDROLYSIS PRODUCT OF THE ANTITUMOR AGENT CARMETHIZOLE

Authors
ANDERSON WK HOUSTON DM JAROSINSKI MA KINDER FR KODE RN VANROEY P SALERNO JM
Citation
Wk. Anderson et al., STRUCTURE, SYNTHESIS, AND ANTITUMOR-ACTIVITY OF THE HYDROLYSIS PRODUCT OF THE ANTITUMOR AGENT CARMETHIZOLE, Drug development research, 30(3), 1993, pp. 143-146
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development research → ACNP
ISSN journal
02724391
Volume
30
Issue
3
Year of publication
1993
Pages
143 - 146
Database
ISI
SICI code
0272-4391(1993)30:3<143:SSAAOT>2.0.ZU;2-#
Abstract
The two isomeric monocarbamates, 2b and 2c, related to the antitumor d rug carmethizole (1) were synthesized and the structure of the carmeth izole hydrolysis product, 2b, was established by X-ray crystallography . The chemical reactivity, toxicity, and antitumor activity of the two monocarbamates, 2b and 2c, were compared with 1. (C) 1993 Wiley-Liss, Inc.