CYTOGENETICAL AND CYTOMORPHOLOGICAL PARAL LELS OF HUMAN-LYMPHOCYTES

Association frequency of human acrocentrical chromosomes is the functi on of the period of interphase of cells and the activity of their prol iferation. This characteristic, therefore, can be used for the analysi s of the dynamics of cellular populations. Variations in the classes o f frequencies of lymphocytes with different associating centrical chro mosomes were compared with the frequency of different classes. The dyn amics of the classes of lymphocytes without associations and with two associating acrocentrics correlated in force and direction with differ ent classes with the diameter up to 0.5 mcm, the fact witnessing their functional unity. They make up a pool of newly-formed activated popul ations of lymphocytes, whose character of dynamics can be used for ana lysing poroliferative and migrational activities of lymphocytes in the initial periods of immunogenesis in lymphoidal organs. The increase i n the number of associations in long-circulating lymphocytes was follo wed by an adequate increase in cellular sizes, the latter being the re flection of their following immunological functions. Changes in freque ncies of associative and different classes in blood and pleural exudat e of patients took place in accordance with the pathogenesis of a conc rete inllness as well as the character of the factors affecting the bo dy.