THE FREQUENCY OF CHROMOSOME-ABERRATIONS I NDUCED BY ACUTE AND CHRONICHYPOXIA IN BONE-MARROW CELLS OF HYPOXIA-RESISTANT RATS

The frequency of hypoxia induced chromosome aberrations in bone marrow cells of rats was researched. According to the resistance to acute hy poxia 2 groups from the population of the laboratory animals were sing led out. One of the groups is low resistant animals capable of being a t <<the height>> 11 thousand metres during 5 minutes, the other group is high resistant animals capable of beihg in the state of acute hypox ia during 25 minutes and even longer. It is shown that acute hypoxia c auses chromosome aberrations in both the groups with the same frequenc y, whereas the following chronic hypoxia (being at <<the height>> of 8 250 m during 3 hours daily for 9 days) induces a truly larger quantity of chromosome aberrations in high resistant rats as compared with low resistant rats.