J. Hebert et al., TRANSLOCATION T(322)(Q27Q11) IN NON-HODGKINS MALIGNANT-LYMPHOMA - CHROMOSOME PAINTING AND MOLECULAR STUDIES, Leukemia, 7(12), 1993, pp. 1971-1974
Translocation t(3;22)(q27;q11) has recently been recognized as a recur
rent abnormality in non-Hodgkin's malignant lymphoma (NHL). A new gene
, LAZ3, has been shown to be involved in NHL with 3q27 rearrangement.
Two patients with B-cell NHL were studied by chromosome painting and S
outhern blot analysis. Fluorescence in situ hybridization to metaphase
chromosomes was shown to be an easy way to detect the chromosomal abn
ormality even in metaphase cells with poorly defined chromosomes. The
gene LAZ3 was rearranged in one patient in the 'major translocation cl
uster region'. The comigration of rearranged LAZ3 and of IGL bands sug
gests that the translocation resulted in the juxtaposition of the two
genes. This juxtaposition makes possible a potential deregulation of t
he LAZ3 gene expression, as previously shown for the MYC and BCL2 gene
s in Burkitt and follicular lymphoma translocations.