TRANSFER IN-VIVO OF TUBERCULIN HYPERSENSITIVITY BY SENSITIZED LYMPHOCYTES

An account is given of the experimental in vivo transfer of PPD-specif ic delayed hypersensitivity with a very small number of autologous lym phocytes pre-sensitised with PPD-specific transfer factor (TF). Transf er was assessed in 17 volunteers both in vivo by means of the Mantoux skin reaction, and in vitro by means of the leukocyte migration inhibi tion test, the lymphocyte locomotion test, and the leukocyte adherence inhibition test. Positivization of the tests suggests that TF trigger s a reaction which expands the effect of hypersensitivity.