APPLICATION OF SUPERCRITICAL-FLUID EXTRACTION AND SUPERCRITICAL-FLUIDCHROMATOGRAPHY TO THE PRODUCTION OF TAXANES AS ANTICANCER DRUGS

Authors
HEATON DM BARTLE KD RAYNER CM CLIFFORD AA
Citation
Dm. Heaton et al., APPLICATION OF SUPERCRITICAL-FLUID EXTRACTION AND SUPERCRITICAL-FLUIDCHROMATOGRAPHY TO THE PRODUCTION OF TAXANES AS ANTICANCER DRUGS, HRC. Journal of high resolution chromatography, 16(11), 1993, pp. 666-670
Citations number
21
Categorie Soggetti
Chemistry Analytical
Journal title
HRC. Journal of high resolution chromatography → ACNP
ISSN journal
09356304
Volume
16
Issue
11
Year of publication
1993
Pages
666 - 670
Database
ISI
SICI code
0935-6304(1993)16:11<666:AOSEAS>2.0.ZU;2-7
Abstract
The supercritical fluid extraction (SFE) of taxicin from the dried nee dles of the English yew tree, Taxus baccata is described. Analysis by supercritical fluid chromatography (SFC) and proton NMR spectroscopy w as used to confirm identity and purity. The extraction efficiency of S FE is comparable with that obtained using liquid solvents. Such taxane s may be used semi-synthetically to prepare potential anti-cancer drug s.