RATIONAL DESIGN FOR CYTOSOLIC DELIVERY OF NUCLEOSIDE MONOPHOSPHATES -SATE AND DTE AS ENZYME-LABILE TRANSIENT PHOSPHATE PROTECTING GROUPS

Authors
PERIGAUD C GOSSELIN G LEFEBVRE I GIRARDET JL BENZARIA S BARBER I IMBACH JL
Citation
C. Perigaud et al., RATIONAL DESIGN FOR CYTOSOLIC DELIVERY OF NUCLEOSIDE MONOPHOSPHATES -SATE AND DTE AS ENZYME-LABILE TRANSIENT PHOSPHATE PROTECTING GROUPS, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2521-2526
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2521 - 2526
Database
ISI
SICI code
0960-894X(1993)3:12<2521:RDFCDO>2.0.ZU;2-Z
Abstract
It was demonstrated that the use of neutral 2',3'-dideoxyuridine phosp hotriesters which incorporate enzyme mediated bioreversible protection such as S-acetylthioethanol (SATE) or dithiodiethanol (DTE) resulted in intracellular delivery of the parent mononucleotide. This point was corroborated by observation of an anti-HIV effect in various cell lin es and decomposition data in cell extracts.