SEMISYNTHETIC SQUALESTATINS - SQUALENE SYNTHASE INHIBITION AND ANTIFUNGAL ACTIVITY - THE SAR OF C6 AND C7 MODIFICATIONS

Authors
GIBLIN GMP BELL R HANCOCK AP HARTLEY CD INGLIS GGA PAYNE JJ PROCOPIOU PA SHINGLER AH SMITH C SPOONER SJ
Citation
Gmp. Giblin et al., SEMISYNTHETIC SQUALESTATINS - SQUALENE SYNTHASE INHIBITION AND ANTIFUNGAL ACTIVITY - THE SAR OF C6 AND C7 MODIFICATIONS, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2605-2610
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2605 - 2610
Database
ISI
SICI code
0960-894X(1993)3:12<2605:SS-SSI>2.0.ZU;2-Z
Abstract
We describe herein a protection/deprotectiOn strategy that enables eff icient transformation of natural Squalestatin S1 into C6 and C7 acyl a nalogues. We present the mammalian and fungal SQS enzyme activity and whole cell antifungal activity of the semi-synthetic Squalestatins.