SYNTHESIS AND ANTIVIRAL ACTIVITY OF 9-(PHOSPHONOALKYNYLOXY)PURINES - NOVEL ACYCLONUCLEOTIDES

Authors
JENNINGS LJ PARRATT MJ
Citation
Lj. Jennings et Mj. Parratt, SYNTHESIS AND ANTIVIRAL ACTIVITY OF 9-(PHOSPHONOALKYNYLOXY)PURINES - NOVEL ACYCLONUCLEOTIDES, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2611-2614
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2611 - 2614
Database
ISI
SICI code
0960-894X(1993)3:12<2611:SAAAO9>2.0.ZU;2-G
Abstract
9-(3-Phosphonoprop-2-ynyloxy)adenine (5) and -guanine (6) were synthes ised and found to have anti-herpesvirus activity. Attempted Arbusov re action of a chloroalkyne (17) with triethyl phosphite unexpectedly gav e the (Z)-2-chloroalkenylphosphonate (19).