SYNTHESIS AND X-RAY STRUCTURE OF A POTENT SUPERPOSITIONAL ANALOG OF THE ENANTIOMERIC FORMS OF FLUOXETINE

Authors
COREY EJ REICHARD GA SARSHAR S
Citation
Ej. Corey et al., SYNTHESIS AND X-RAY STRUCTURE OF A POTENT SUPERPOSITIONAL ANALOG OF THE ENANTIOMERIC FORMS OF FLUOXETINE, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2635-2636
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2635 - 2636
Database
ISI
SICI code
0960-894X(1993)3:12<2635:SAXSOA>2.0.ZU;2-0
Abstract
4-Phenyl-4-(p-trifluoromethylphenoxy)piperidine (1), a molecule which approximates a superimposition of the enantiomers of fluoxetine (2a an d 2b), has been synthesized and found to be somewhat more active than 2a or 2b as an inhibitor of serotonin uptake.