USE OF 2-DIPHENYLMETHYLSILYLETHYL (DPSE) PROTECTING GROUP IN OLIGONUCLEOTIDE SYNTHESIS VIA PHOSPHORAMIDITE APPROACH

Authors
RAVIKUMAR VT SASMOR H COLE DL
Citation
Vt. Ravikumar et al., USE OF 2-DIPHENYLMETHYLSILYLETHYL (DPSE) PROTECTING GROUP IN OLIGONUCLEOTIDE SYNTHESIS VIA PHOSPHORAMIDITE APPROACH, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2637-2640
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2637 - 2640
Database
ISI
SICI code
0960-894X(1993)3:12<2637:UO2(PG>2.0.ZU;2-G
Abstract
2-Diphenylmethylsilylethyl (DPSE) is a new protecting group for the in ternucleotidic bonds in the synthesis of deoxyribooligonucleotides by the phosphoramidite approach. This group is stable to acidic condition s and can be removed under mild conditions using aqueous ammonium hydr oxide.