SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2-DESAMINO AND 4-DEOXY ANALOGS OF 5,10-DIDEAZATETRAHYDROFOLIC ACID (DDATHF)

Authors
SHIH C HU Y GOSSETT LS HABECK LL MENDELSOHN LG GRINDEY GB
Citation
C. Shih et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2-DESAMINO AND 4-DEOXY ANALOGS OF 5,10-DIDEAZATETRAHYDROFOLIC ACID (DDATHF), Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2657-2660
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2657 - 2660
Database
ISI
SICI code
0960-894X(1993)3:12<2657:SABO2A>2.0.ZU;2-B
Abstract
Either the 2-amino or the 4-oxo group of the potent GAR formyltransfer ase inhibitor 5,10-dideazatetrahydrofolic acid (DDATHF) was replaced w ith a hydrogen atom and their biological activity evaluated.